Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015).
Abstract
Background: The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.
Patients and methods: A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.
Results: The median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.
Conclusion: The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.
Author
Shah, Jatin P
Levyn, Helena
Valero, Cristina
Adilbay, Dauren
Eagan, Alana
Zheng, Junting
Gonen, Mithat
Cohen, Marc
Patel, Snehal
Ganly, Ian
Pai, Prathamesh
Castelnuovo, Paolo
Gao, Fang Ju
Piazza, Cesare
Nicolai, Piero
Panizza, Ben
Bowman, James
Barnett, Catherine
Kowalski, Luiz P
Toledo, Ronaldo
Fliss, Dan M
DeAlmeida, John
Witterick, Ian
Herman, Philippe
Fontanella, Walter
Aniceto, Gregorio Sanchez
Hosal, Sefik
Ozer, Serdar
Iyer, Subramania
Harvey, Richard
Leemans, C Rene
Hendrickx, Jan-Jaap
Figari, Marcelo
Boccalatte, Luis
Nibu, Ken Ichi
Clarke, Peter
Rennie, Catherine
Ming, Zhu Yi
Cernea, Claudio
Goncalves, Sergio
Schlosser, Rodney
Dias, Fernando
Sargi, Zoukaa
Ahmed, Shahzada
Golusinski, Wojciech
Kim, Se Heon
Su, Shirley Y
Raza, Shaan M
DeMonte, Franco
Hanna, Ehab
Levyn, Helena
Valero, Cristina
Adilbay, Dauren
Eagan, Alana
Zheng, Junting
Gonen, Mithat
Cohen, Marc
Patel, Snehal
Ganly, Ian
Pai, Prathamesh
Castelnuovo, Paolo
Gao, Fang Ju
Piazza, Cesare
Nicolai, Piero
Panizza, Ben
Bowman, James
Barnett, Catherine
Kowalski, Luiz P
Toledo, Ronaldo
Fliss, Dan M
DeAlmeida, John
Witterick, Ian
Herman, Philippe
Fontanella, Walter
Aniceto, Gregorio Sanchez
Hosal, Sefik
Ozer, Serdar
Iyer, Subramania
Harvey, Richard
Leemans, C Rene
Hendrickx, Jan-Jaap
Figari, Marcelo
Boccalatte, Luis
Nibu, Ken Ichi
Clarke, Peter
Rennie, Catherine
Ming, Zhu Yi
Cernea, Claudio
Goncalves, Sergio
Schlosser, Rodney
Dias, Fernando
Sargi, Zoukaa
Ahmed, Shahzada
Golusinski, Wojciech
Kim, Se Heon
Su, Shirley Y
Raza, Shaan M
DeMonte, Franco
Hanna, Ehab
Citations
Altmetric:
Date
2024-05-21
Type
Article
Subject
Surgery, Oncology. Pathology.
Collections
Citation
Shah JP, Levyn H, Valero C, Adilbay D, Eagan A, Zheng J, Gonen M, Cohen M, Patel S, Ganly I, Pai P, Castelnuovo P, Gao FJ, Piazza C, Nicolai P, Panizza B, Bowman J, Barnett C, Kowalski LP, Toledo R, Fliss DM, DeAlmeida J, Witterick I, Herman P, Fontanella W, Aniceto GS, Hosal S, Ozer S, Iyer S, Harvey R, Leemans CR, Hendrickx JJ, Figari M, Boccalatte L, Nibu KI, Clarke P, Rennie C, Ming ZY, Cernea C, Goncalves S, Schlosser R, Dias F, Sargi Z, Ahmed S, Golusinski W, Kim SH, Su SY, Raza SM, DeMonte F, Hanna E. Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015). Head Neck. 2024 May 21. doi: 10.1002/hed.27746. Epub ahead of print.
Journal / Source Title
Head and Neck
DOI
10.1002/hed.27746
PMID
38770972
Publisher
John Wiley and Sons
Publisher’s URL
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0347