Cardiac prehabilitation, rehabilitation and education in first-time atrial fibrillation (AF) ablation (CREED AF): Study protocol for a randomised controlled trial.
Chandan, Nakul Matthews, Violet Lachlan, Thomas Lim, Ven Gee Joshi, Shivam Hee, Siew Wan Noufaily, Angela Parkes, Edward Patel, Shilpa
Chandan, Nakul
Matthews, Violet
Lachlan, Thomas
Lim, Ven Gee
Joshi, Shivam
Hee, Siew Wan
Noufaily, Angela
Parkes, Edward
Patel, Shilpa
Abstract
Atrial fibrillation (AF) is a common arrhythmia [1–3] and is independently associated with
increased morbidity and all-cause mortality [3–8]. Two-thirds of people with AF have at least
intermittent symptoms which can be disabling and can markedly impair health-related quality
of life (HRQoL) [9, 10]. Furthermore, AF is a growing epidemic due to the ageing population,
chronic cardiovascular diseases, and the accumulation of AF related risk factors, such as diabetes,
obesity, hypertension, alcohol, and smoking [6, 11, 12]. Current AF management is largely
focused on stroke prevention via anticoagulation, and heart failure prevention with ventricular
rate or rhythm control strategies (anti-arrhythmic drugs and catheter or surgical ablation) [3,
13] and is a top priority in the UK National Health Service (NHS) long-term plan [14].
Although current strategies can be effective in the short term, long-term success is limited and
there is a failure to address key patient outcomes including exercise capacity and HRQoL.
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Date
2024-10-03
Type
Article
Other
Other
Subject
Collections
Citation
Nakul Chandan1,2, Violet Matthews1,3, Hejie HeID 1,4, Thomas Lachlan1,4, Ven Gee LimID 1,4, Shivam JoshiID 1,3, Siew Wan HeeID 1,3, Angela Noufaily4, Edward Parkes1,4, Shilpa Patel1,4, Lazaros Andronis4, Joanna Shakespeare1,4, Helen Eftekhari1,4, Asad Ali1, Gordon McGregor1,2,4, Faizel OsmanID 1,2,4*
Journal / Source Title
PLoS ONE
DOI
10.1371/journal.pone.0310951
PMID
39361572
Publisher
Plos One
Publisher’s URL
https://doi.org/10.1371/journal.pone.0310951