Development and validation of an improved classification and risk stratification system for carotid body tumors: multinational collaborative cohort study.
Abstract
Background: This study aims to develop and validate a new classification system that better predicts combined risk of neurological and neurovascular complications following CBT surgery, crucial for treatment decision-making.
Methods: Multinational retrospective cohort study with 199 consecutive cases. A cohort of 132 CBT cases was used to develop the new classification. To undertake external validation, assessment was made between the actual complication rate and predicted risk by the model on an independent cohort (n = 67).
Results: Univariate analyses showed statistically significant associations between developing a complication and the following factors: craniocaudal dimension, volume, Shamblin classification, and Mehanna types. In the multivariate prognostic model, only Mehanna type remained as a significant risk predictor. The risk of developing complications increases with increasing Mehanna type.
Conclusions: We have developed and then validated a new classification and risk stratification system for CBTs, which demonstrated better prognostic power for the risk of developing neurovascular complications after surgery.
Author
Mehanna, Hisham
Mistry, Pankaj
Golusinski, Pawel
Di Maio, Pasquale
Nankivell, Paul
Snider, Francesco
Ferrante, Angela M R
Montalto, Nausica
Nicolai, Piero
Marcantoni, Alessandra
Grandi, Cesare
Zavatta, Marco
Grego, Franco
Malec, Kataryna
Hosal, Sefik
Suslu, Nilda
Kuscu, Oguz
Torrealba, Ignacio
Valdes, Francisco
Sharma, Neil
Ayuk, John
Monksfield, Peter
Irving, Richard
Dunn, Janet A
Kay, Mark
Borsetto, Daniele
Mistry, Pankaj
Golusinski, Pawel
Di Maio, Pasquale
Nankivell, Paul
Snider, Francesco
Ferrante, Angela M R
Montalto, Nausica
Nicolai, Piero
Marcantoni, Alessandra
Grandi, Cesare
Zavatta, Marco
Grego, Franco
Malec, Kataryna
Hosal, Sefik
Suslu, Nilda
Kuscu, Oguz
Torrealba, Ignacio
Valdes, Francisco
Sharma, Neil
Ayuk, John
Monksfield, Peter
Irving, Richard
Dunn, Janet A
Kay, Mark
Borsetto, Daniele
Citations
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Date
2021-08-21
Type
Article
Subject
Surgery, Ear, Nose & Throat, Endocrinology
Collections
Citation
Mehanna H, Mistry P, Golusinski P, Di Maio P, Nankivell P, Snider F, Ferrante AMR, Montalto N, Nicolai P, Marcantoni A, Grandi C, Zavatta M, Grego F, Malec K, Hosal S, Suslu N, Kuscu O, Torrealba I, Valdes F, Sharma N, Ayuk J, Monksfield P, Irving R, Dunn JA, Kay M, Borsetto D. Development and validation of an improved classification and risk stratification system for carotid body tumors: Multinational collaborative cohort study. Head Neck. 2021 Nov;43(11):3448-3458. doi: 10.1002/hed.26844. Epub 2021 Aug 21
Journal / Source Title
Head and Neck
DOI
10.1002/hed.26844
PMID
34418219
Publisher
John Wiley and Sons
Publisher’s URL
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0347