Prevalence of invasive lung cancer in pure ground glass nodules less than 30 mm: A systematic review
AlShammari, Abdullah Patel, Akshay Boyle, Mark Proli, Chiara Gallesio, Jose Alvarez Wali, Anuj De Sousa, Paulo Lim, Eric
AlShammari, Abdullah
Patel, Akshay
Boyle, Mark
Proli, Chiara
Gallesio, Jose Alvarez
Wali, Anuj
De Sousa, Paulo
Lim, Eric
Abstract
All published studies were retrospective (n = 28) and the majority conducted in Asia (n = 25). Baseline patient cohorts were mainly from published surgical series (n = 22) or lung cancer screening programs (n = 6). The proportion of minimally invasive and invasive cancer ranged from 0.9 % to 100 % with a pooled prevalence of 42.4 % [95 % CI: 0.28, 0.57]. Considerable heterogeneity was observed (I2 =99 %) and patient selection was the most significant contribution, accounting for 73 % of the observed heterogeneity (p < 0.0001). Meta-regression based on size selection and country of investigation revealed no significant contribution to effect size effect or heterogeneity.
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2024-11-05
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AlShammari A, Patel A, Boyle M, Proli C, Gallesio JA, Wali A, De Sousa P, Lim E. Prevalence of invasive lung cancer in pure ground glass nodules less than 30 mm: A systematic review. Eur J Cancer. 2024 Dec;213:115116. doi: 10.1016/j.ejca.2024.115116. Epub 2024 Nov 5.