Cost-effectiveness of osteoporotic fracture risk assessment in people with intellectual disabilities: a UK NHS modelling study
Png, May Ee Frighi, Valeria Holt, Tim Adrian Achana, Felix Smith, Margaret C Collins, Gary Stephen Roast, Jan Petrou, Stavros
Png, May Ee
Frighi, Valeria
Holt, Tim Adrian
Achana, Felix
Smith, Margaret C
Collins, Gary Stephen
Roast, Jan
Petrou, Stavros
Abstract
Objectives: We compared the cost-effectiveness of alternative fracture risk assessment strategies for people with intellectual disabilities (ID) aged ≥40 years from a UK National Health Services perspective over a lifetime horizon.
Design: Cost-effectiveness analysis using a lifetime decision-analytical model.
Setting: UK primary care, with data from literature and national databases.
Participants: People with ID.
Interventions: Three strategies were assessed: (S1) Risk assessment using the UK QFracture score; (S2) use of IDFracture (a fracture risk prediction tool specifically developed for adults with ID); and (S3) conducting a one-time dual-energy X-ray absorptiometry (DXA) scan in all. S1 and S2 were followed by DXA scan for those at risk. At-risk individuals received treatment according to UK practice (bisphosphonates plus vitamin D and calcium for osteoporosis, and vitamin D and calcium alone for osteopenia).
Primary outcome measures: Direct healthcare costs and quality-adjusted life years (QALYs), and incremental cost-effectiveness ratio (ICER).
Results: In the base case, S2 (ICER: -£2568/QALY) was dominant (ie, less costly and more effective) and S3 (ICER: £1678/QALY) was cost-effective relative to S1 for major osteoporotic fracture (MOF). For hip fracture, S2 (ICER: £32 116/QALY) and S3 (ICER: £49 536/QALY) were not cost-effective relative to S1 under the National Institute for Health and Care Excellence-recommended cost-effectiveness thresholds. Findings from the sensitivity analyses were predominantly consistent with the base-case results. Subgroup analyses showed that age-specific and gender-specific strategies could be used.
Conclusion: For people with ID aged ≥40 years, a proactive approach to risk assessment for MOF is not only clinically beneficial, but also cost-effective.
MIDER Authors
Affiliations
Date
2026-04-17
Type
Article
Collections
Citation
Png ME, Frighi V, Holt TA, Achana F, Smith MC, Collins GS, Roast J, Petrou S. Cost-effectiveness of osteoporotic fracture risk assessment in people with intellectual disabilities: a UK NHS modelling study. BMJ Open. 2026 Apr 17;16(4):e110008. doi: 10.1136/bmjopen-2025-110008.