Development, Rasch analysis and validation of the kidney symptom burden questionnaire (KSB-Q)
Kyte, Derek Fletcher, Benjamin R Horton, Mike Damery, Sarah Aiyegbusi, Olalekan Lee Anderson, Nicola Bissell, Andrew Calvert, Melanie Cockwell, Paul Ferguson, James
Kyte, Derek
Fletcher, Benjamin R
Horton, Mike
Damery, Sarah
Aiyegbusi, Olalekan Lee
Anderson, Nicola
Bissell, Andrew
Calvert, Melanie
Cockwell, Paul
Ferguson, James
Abstract
Background: Increasingly, patient-reported outcome measures (PROMs) are used to monitor chronic kidney disease (CKD) symptoms in routine clinical practice. However, such symptom measurement currently requires completion of multiple, often lengthy, PROMs, which may lead to questionnaire fatigue, lower levels of completion, and missing data. Moreover, many CKD-specific PROMs lack evidence of important measurement properties and few were developed using contemporary psychometric methods. The study objective was to develop and validate a short-form kidney symptom burden questionnaire (KSB-Q).
Methods: A cross-sectional item pool survey was distributed to adults (≥18 years) with CKD stages 3-5 [including individuals not receiving kidney replacement therapy (KRT), those receiving dialysis and those with a functioning kidney transplant] in England (Birmingham, London, Sheffield, and Nottingham) from March to September 2022. Rasch measurement was used to assess the psychometric properties of the item pool. Cognitive debriefing interviews were conducted to evaluate content validity.
Results: In total, 419/1464 participants responded (29% response rate), with 28% receiving dialysis and 30% in receipt of a kidney transplant. Rasch analysis indicated that nine items, one for each of nine symptom domains (fatigue, pain, memory/concentration, poor sleep, skin problems, gastrointestinal problems, dizziness, restless legs, and shortness of breath), formed a PROM with strong psychometric properties (including statistically acceptable reliability, test-retest reliability, and validity). Cognitive debriefing and survey responses confirmed content validity encompassing relevance, comprehensiveness, and clarity.
Conclusions: The KSB-Q is a nine-item PROM measuring somatic symptoms. The KSB-Q demonstrates strong psychometric properties in patients with CKD stages 3-5, including those not receiving KRT, individuals receiving dialysis, and those with a functioning kidney transplant.
MIDER Authors
Date
2025-04-24
Type
Article
Subject
Kidney diseases, Surveys and questionnaires, Signs and symptoms
Collections
Citation
Kyte D, Fletcher BR, Horton M, Damery S, Aiyegbusi OL, Anderson N, Bissell A, Calvert M, Cockwell P, Ferguson J, Paap MCS, Sidey-Gibbons C, Turner N, Verdi R, Slade A. Development, Rasch analysis and validation of the kidney symptom burden questionnaire (KSB-Q). Clin Kidney J. 2025 Apr 24;18(5):sfaf112. doi: 10.1093/ckj/sfaf112.
Journal / Source Title
Clinical Kidney Journal
DOI
10.1093/ckj/sfaf112
PMID
40342621
Publisher
Oxford University Press
Publisher’s URL
https://academic.oup.com/ckj