Approach to Mycosis Fungoides in children: Consensus-based recommendations
Abstract
Background: Pediatric Mycosis fungoides (MF) management extrapolates from adult guidelines, despite differing clinical aspects. Recommendations are essential to address unique challenges in this distinct patient group.
Objective: This project aims to derive consensus recommendations for pediatric MF management.
Methods: Experts from pediatric dermatology, general dermatology, dermatopathology, and pediatric hematology-oncology (N = 83) were invited to contribute to consensus recommendations. The process involved 3 electronic Delphi rounds, concluding with a final consensus meeting using a modified Nominal Group Technique for unresolved items.
Results: Consensus included more clinical severity measures than tumor-node-metastasis-blood staging: pruritus, functional or esthetic impairment (eg, palms, soles, genitalia), quality of life impact, and psychological aspects (eg, embarrassment, anxiety, depression), plus parental anxiety. Ten recommendations were made for managing early and advanced pediatric MF. Disagreement emerged in choosing therapies beyond stage I of the disease.
Discussion: This multinational initiative aimed to standardize optimal pediatric MF management and successfully generated consensus recommendations. Additional work is needed for structured, prospective protocols in advanced-stage pediatric MF.
Limitations: Lack of pediatric hematologists-oncologists and patients' representatives.
Conclusion: Documentation of extended clinical severity and outcome measures is recommended. Addressing the need for structured protocols in advanced-stage pediatric MF and implementing systematic, prospective data collection is crucial.
Author
Zvulunov, Alex
Neale, Holly
Stern, Jonah
Santaguida, Pasqualina
Stein, Amy Buros
Koh, Mark
Eichenfield, Lawrence F
Guitart, Joan
Goebeler, Matthias
Scarisbrick, Julia
Willemze, Rein
Coughlin, Carrie C
George, Renu
Brazzelli, Valeria
Marschalkó, Márta
Belousova, Irena
Querfeld, Christiane
Bagot, Martine
Szepietowski, Jacek C
Papadavid, Evangelina
Quaglino, Pietro
Hoeger, Peter
Ortiz-Romero, Pablo L
Nikolaou, Vasiliki
Dummer, Reinhard
Aung, Phyu P
Lawley, Leslie
Morel, Kimberly D
Ngan, Bo
Wain, Mary
Gameiro, Ana
Lacy-Niebla, Rosa María
Pope, Elena
Neale, Holly
Stern, Jonah
Santaguida, Pasqualina
Stein, Amy Buros
Koh, Mark
Eichenfield, Lawrence F
Guitart, Joan
Goebeler, Matthias
Scarisbrick, Julia
Willemze, Rein
Coughlin, Carrie C
George, Renu
Brazzelli, Valeria
Marschalkó, Márta
Belousova, Irena
Querfeld, Christiane
Bagot, Martine
Szepietowski, Jacek C
Papadavid, Evangelina
Quaglino, Pietro
Hoeger, Peter
Ortiz-Romero, Pablo L
Nikolaou, Vasiliki
Dummer, Reinhard
Aung, Phyu P
Lawley, Leslie
Morel, Kimberly D
Ngan, Bo
Wain, Mary
Gameiro, Ana
Lacy-Niebla, Rosa María
Pope, Elena
Citations
Altmetric:
Date
2024-08-23
Type
Article
Conference Output
Conference Output
Subject
Oncology. Pathology., Dermatology, Paediatrics
Collections
Citation
Zvulunov A, Neale H, Stern J, Santaguida P, Stein AB, Koh M, Eichenfield LF, Guitart J, Goebeler M, Scarisbrick J, Willemze R, Coughlin CC, George R, Brazzelli V, Marschalkó M, Belousova I, Querfeld C, Bagot M, Szepietowski JC, Papadavid E, Quaglino P, Hoeger P, Ortiz-Romero PL, Nikolaou V, Dummer R, Aung PP, Lawley L, Morel KD, Ngan B, Wain M, Gameiro A, Lacy-Niebla RM, Pope E. Approach to Mycosis Fungoides in children: Consensus-based recommendations. J Am Acad Dermatol. 2024 Dec;91(6):1078-1085. doi: 10.1016/j.jaad.2024.07.1501. Epub 2024 Aug 23.
Journal / Source Title
Journal of the American Academy of Dermatology
DOI
10.1016/j.jaad.2024.07.1501
PMID
39181404
Publisher
Mosby
Publisher’s URL
http://www.sciencedirect.com/science/journal/01909622