Loading...
Measures of intracranial compartments in acute intracerebral haemorrhage: Data from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial (RIGHT-2)
Krishnan, Kailash Dineen, Robert A. Sprigg, Nikola Bath, Philip M.
Krishnan, Kailash
Dineen, Robert A.
Sprigg, Nikola
Bath, Philip M.
Abstract
Background and purpose Intracerebral haemorrhage volume (ICHV) is prognostically important but does not account for intracranial volume (ICV) and cerebral parenchymal volume (CPV). We assessed measures of intracranial compartments in acute ICH using computerised tomography scans and whether ICHV/ICV and ICHV/CPV predict functional outcomes. We also assessed if cistern effacement, midline shift, old infarcts, leukoaraiosis and brain atrophy were associated with outcomes. Methods Data from 133 participants from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial trial were analysed. Measures included ICHV (using ABC/2) and ICV (XYZ/2) (by independent observers); ICHV, ICV and CPV (semiautomated segmentation, SAS); atrophy (intercaudate distance, ICD, Sylvian fissure ratio, SFR); midline shift; leukoaraiosis and cistern effacement (visual assessment). The effects of these measures on death at day 4 and poor functional outcome at day 90 (modified Rankin scale, mRS of >3) was assessed. Results ICV was significantly different between XYZ and SAS: mean (SD) of 1357 (219) vs 1420 (196), mean difference (MD) 62 mL (pCopyright © 2023 BMJ Publishing Group. All rights reserved.
MIDER Authors
Affiliations
Citations
Altmetric:
Date
2023
Type
Article
Collections
Citation
Krishnan, K., Law, Z.K., Woodhouse, L.J., Dineen, R.A., Sprigg, N., Wardlaw, J.M. and Bath, P.M. (2023) 'Measures of intracranial compartments in acute intracerebral haemorrhage: Data from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial (RIGHT-2)', Stroke and Vascular Neurology, 8(2), pp. 151–160. doi: 10.1136/svn-2021-001375. https://doi.org/10.1136/svn-2021-001375.