Incidents in molecular pathology: frequency and causes during routine testing
Abstract
Context.—: Errors in laboratory medicine could compromise patient safety. Good laboratory practice includes identifying and managing nonconformities in the total test process. Varying error percentages have been described in other fields but are lacking for molecular oncology.
Objectives.—: To gain insight into incident causes and frequency in the total test process from 8 European institutes routinely performing biomarker tests in non-small cell lung cancer and colorectal cancer.
Design.—: All incidents documented in 2018 were collected from all hospital services for pre-preanalytical entries before the biomarker test, as well as specific incidents for biomarker tests.
Results.—: There were 5185 incidents collected, of which 4363 (84.1%) occurred in the pre-preanalytical phase (all hospital services), 2796 of 4363 (64.1%) related to missing or incorrect request form information. From the other 822 specific incidents, 166 (20.2%) were recorded in the preanalytical phase, 275 (33.5%) in the analytical phase, and 194 (23.6%) in the postanalytical phase, mainly due to incorrect report content. Only 47 of 822 (5.7%) incidents were recorded in the post-postanalytical phase, and 123 (15.0%) in the complete total test process. For 17 of 822 (2.1%) incidents the time point was unknown. Pre-preanalytical incidents were resolved sooner than incidents on the complete process (mean 6 versus 60 days). For 1215 of 5168 (23.5%) incidents with known causes a specific action was undertaken besides documenting them, not limited to accredited institutes.
Conclusions.—: There was a large variety in the number and extent of documented incidents. Correct and complete information on the request forms and final reports are highly error prone and require additional focus.
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Date
2021-10-01
Type
Article
Subject
Public health. Health statistics. Occupational health. Health education, Practice of medicine, Oncology. Pathology.
Collections
Citation
Keppens C, Van Royen Y, Brysse A, Cotteret S, Høgdall E, Kuhlmann TP, O'Sullivan B, Pauwels P, Pauwels S, Rot M, Vanderheyden N, Van Hee I, Dequeker EM. Incidents in Molecular Pathology: Frequency and Causes During Routine Testing. Arch Pathol Lab Med. 2021 Oct 1;145(10):1270-1279. doi: 10.5858/arpa.2020-0152-OA
Journal / Source Title
Archives of Pathology & Laboratory Medicine
DOI
10.5858/arpa.2020-0152-OA
PMID
33406246
Publisher
College of American Pathologists
Publisher’s URL
https://meridian.allenpress.com/aplm