Classification of paediatric brain tumours by diffusion weighted imaging and machine learning
Novak, Jan Zarinabad, Niloufar Rose, Heather Arvanitis, Theodoros MacPherson, Lesley Pinkey, Benjamin Oates, Adam Hales, Patrick Grundy, Richard Auer, Dorothee
Novak, Jan
Zarinabad, Niloufar
Rose, Heather
Arvanitis, Theodoros
MacPherson, Lesley
Pinkey, Benjamin
Oates, Adam
Hales, Patrick
Grundy, Richard
Auer, Dorothee
Abstract
To determine if apparent diffusion coefficients (ADC) can discriminate between posterior fossa brain tumours on a multicentre basis. A total of 124 paediatric patients with posterior fossa tumours (including 55 Medulloblastomas, 36 Pilocytic Astrocytomas and 26 Ependymomas) were scanned using diffusion weighted imaging across 12 different hospitals using a total of 18 different scanners. Apparent diffusion coefficient maps were produced and histogram data was extracted from tumour regions of interest. Total histograms and histogram metrics (mean, variance, skew, kurtosis and 10th, 20th and 50th quantiles) were used as data input for classifiers with accuracy determined by tenfold cross validation. Mean ADC values from the tumour regions of interest differed between tumour types, (ANOVA P < 0.001). A cut off value for mean ADC between Ependymomas and Medulloblastomas was found to be of 0.984 × 10-3 mm2 s-1 with sensitivity 80.8% and specificity 80.0%. Overall classification for the ADC histogram metrics were 85% using Naïve Bayes and 84% for Random Forest classifiers. The most commonly occurring posterior fossa paediatric brain tumours can be classified using Apparent Diffusion Coefficient histogram values to a high accuracy on a multicentre basis.
MIDER Authors
Affiliations
University of Birmingham; Birmingham Women's and Children's NHS Foundation Trust; Aston University; University of Warwick; UCL Great Ormond Street Institute of Child Health; University of Nottingham; NIHR Nottingham Biomedical Research Centre; Nottingham University Hospitals NHS Trust; Alder Hey Children's Hospital NHS Foundation Trust; Great Ormond Street Hospital for Children NHS Foundation Trust; Newcastle Upon Tyne Hospitals NHS Foundation Trust
Date
2021-02-04
Type
Article
Collections
Citation
Novak J, Zarinabad N, Rose H, Arvanitis T, MacPherson L, Pinkey B, Oates A, Hales P, Grundy R, Auer D, Gutierrez DR, Jaspan T, Avula S, Abernethy L, Kaur R, Hargrave D, Mitra D, Bailey S, Davies N, Clark C, Peet A. Classification of paediatric brain tumours by diffusion weighted imaging and machine learning. Sci Rep. 2021 Feb 4;11(1):2987. doi: 10.1038/s41598-021-82214-3.