Assessment of predictSURE IBD assay in a multinational cohort of patients with inflammatory bowel disease
Abstract
BACKGROUND AND AIMS: PredictSURE IBD is a prognostic blood test that classifies newly diagnosed, treatment-naïve Inflammatory Bowel Disease (IBD) patients into 'IBDhi' (high-risk) or 'IBDlo' (low-risk) groups (risk of future aggressive disease). We evaluated this assay in a multinational cohort and explored the effect of concomitant corticosteroids on its discrimination.
METHODS: One hundred thirty-six (71 Ulcerative colitis [UC], 65 Crohn's Disease [CD]) and 41 (15 UC, 26 CD) patients with active IBD were 'unexposed' and 'exposed', respectively, to corticosteroids at baseline blood sampling. The number of treatment escalations, time to first escalation, and need for repeated escalations were compared between the biomarker subgroups. Another 20 patients (13 UC, 7 CD) were longitudinally sampled over 6 weeks after commencing corticosteroids.
RESULTS: In corticosteroids-naïve UC and CD patients, all bowel surgeries (n = 6) and multiple therapy escalations (n = 10) occurred in IBDhi patients. IBDhi UC patients required significantly more treatment escalations, had a shorter time to first escalation, and a greater need for multiple escalations than IBDlo patients. No statistically significant differences were observed among CD patients. In corticosteroid-exposed patients, 66.6% of 'misclassifications' were IBDlo patients who required escalations. Among corticosteroid-treated patients with longitudinal sampling, 81.3% of those classified as IBDhi before steroids switched to IBDlo during therapy.
CONCLUSIONS: No significant differences in treatment escalations were observed between biomarker-defined subgroups in CD. However, IBDhi UC patients required significantly earlier and more frequent therapy escalations, highlighting the need to further investigate PredictSURE IBD in UC. Notably, the discrimination ability of the biomarker was unreliable in patients receiving corticosteroid therapy.
Author
Alsoud, Dahham
Noor, Nurulamin M
Chen, Lea Ann
Abadom, Vivian
Anderson, Simon H C
Ardolli, Lediona
Axelrad, Jordan
Bossuyt, Peter
Croitoru, Kenneth
Damas, Oriana M
Deng, Lily
Deepak, Parakkal
Negro, Juan De La Revilla
de Silva, Shanika
Ferrante, Marc
Hills, Karen
Irving, Peter M
Lindsay, James O
Lukin, Dana J
Lyons, Paul A
McKinney, Eoin F
Oliva-Hemker, Maria
Oneto, Caterina
Patel, Roohi
Parkes, Miles
Pouillon, Lieven
Sabino, João
Saubermann, Lawrence J
Sauk, Jenny S
Sheibani, Sarah
Smith, Kenneth G C
Sultan, Keith S
Tham, Tony C
Verstockt, Sare
Vrabie, Raluca
Weidner, Melissa
Yu, Huimin
Verstockt, Bram
Lee, James C
Vermeire, Séverine
Noor, Nurulamin M
Chen, Lea Ann
Abadom, Vivian
Anderson, Simon H C
Ardolli, Lediona
Axelrad, Jordan
Bossuyt, Peter
Croitoru, Kenneth
Damas, Oriana M
Deng, Lily
Deepak, Parakkal
Negro, Juan De La Revilla
de Silva, Shanika
Ferrante, Marc
Hills, Karen
Irving, Peter M
Lindsay, James O
Lukin, Dana J
Lyons, Paul A
McKinney, Eoin F
Oliva-Hemker, Maria
Oneto, Caterina
Patel, Roohi
Parkes, Miles
Pouillon, Lieven
Sabino, João
Saubermann, Lawrence J
Sauk, Jenny S
Sheibani, Sarah
Smith, Kenneth G C
Sultan, Keith S
Tham, Tony C
Verstockt, Sare
Vrabie, Raluca
Weidner, Melissa
Yu, Huimin
Verstockt, Bram
Lee, James C
Vermeire, Séverine
Date
2025-07-11
Type
Article
Subject
Biomarker, Tumour, Haematologic Tests, prognosis, Prognosis
Collections
Citation
Alsoud D, Noor NM, Chen LA, Abadom V, Anderson SHC, Ardolli L, Axelrad J, Bossuyt P, Croitoru K, Damas OM, Deng L, Deepak P, Negro JR, de Silva S, Ferrante M, Hills K, Irving PM, Lindsay JO, Lukin DJ, Lyons PA, McKinney EF, Oliva-Hemker M, Oneto C, Patel R, Parkes M, Pouillon L, Sabino J, Saubermann LJ, Sauk JS, Sheibani S, Smith KGC, Sultan KS, Tham TC, Verstockt S, Vrabie R, Weidner M, Yu H, Verstockt B, Lee JC, Vermeire S. Assessment of PredictSURE IBD Assay in a Multinational Cohort of Patients With Inflammatory Bowel Disease. United European Gastroenterol J. 2025 Oct;13(8):1525-1540. doi: 10.1002/ueg2.70050. Epub 2025 Jul 11
Journal / Source Title
United European Gastroenterology Journal
DOI
10.1002/ueg2.70050
PMID
40641434
Publisher
Sage Publications
Publisher’s URL
https://pmc.ncbi.nlm.nih.gov/journals/?term=101606807