Endocompass project: research roadmap for pituitary and neuroendocrine tumor endocrinology
Castano, Justo P Dattani, Mehul Tulsidas Grozinsky-Glasberg, Simona Karavitaki, Niki Pavel, Marianne E Andoniadou, Cynthia Alexandraki, Krystallenia Capatina, Cristina Cerbone, Manuela Ferone, Diego
Castano, Justo P
Dattani, Mehul Tulsidas
Grozinsky-Glasberg, Simona
Karavitaki, Niki
Pavel, Marianne E
Andoniadou, Cynthia
Alexandraki, Krystallenia
Capatina, Cristina
Cerbone, Manuela
Ferone, Diego
Abstract
Background
Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.
Methods
Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in pituitary and neuroendocrine tumor endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.
Results
Research priorities encompass congenital and acquired disorders, tumor development and progression, and neuroendocrine neoplasms. Key areas include genetic/epigenetic factors, tumor microenvironment, personalized treatment approaches, developing preclinical models, and implementing artificial intelligence. Special emphasis is placed on aggressive tumors, hypothalamic syndromes, and establishing pan-European biobanks and databases.
Conclusions
This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into pituitary-neuroendocrine disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.
MIDER Authors
Date
2025-11-27
Type
Article
Subject
Thyroid diseases
Collections
Citation
Castano JP, Dattani MT, Grozinsky-Glasberg S, Karavitaki N, Pavel ME, Andoniadou C, Alexandraki K, Capatina C, Cerbone M, Ferone D, Gan HW, Hofland J, Hofland L, Ibanez-Costa A, Ilie MD, Isidori AM, Korbonits M, Kos-Kudła B, Maghnie M, Mantovani G, Marazuela M, Raverot G, Scarpa A, Schilbach K, Theodoropoulou M, van Santen HM, Zatelli MC. EndoCompass Project: Research Roadmap for Pituitary and Neuroendocrine Tumor Endocrinology. Horm Res Paediatr. 2025 Nov 27:1-16. doi: 10.1159/000549145. Epub ahead of print.
Journal / Source Title
Hormone research in paediatrics
DOI
10.1159/000549145
PMID
41308051
Publisher
Karger