Epidemiology and mortality of Cushing's syndrome.
Abstract
Endogenous Cushing's syndrome (CS) is a rare endocrine disorder characterised by excess cortisol secretion due to either ACTH-dependent conditions [commonly an ACTH-producing pituitary adenoma (Cushing's disease)] or ACTH-independent causes (with most common aetiology being a benign adrenal adenoma). Overall, the annual incidence of CS ranges between 1.8 and 3.2 cases per million population. Mortality in active CS is elevated compared to the general population, and a number of studies support the view that survival is also compromised even after apparent successful treatment. The main cause of death is cardiovascular disease highlighting the negative impact of cortisol excess on cardiovascular risk factors. Early diagnosis and prompt treatment of the cortisol excess, as well as vigilant monitoring and stringent control of cardiovascular risk factors are key elements for the long-term prognosis of these patients.
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Date
2021-03-15
Type
Article
Other
Other
Subject
Ear, Nose & Throat
Collections
Citation
Hakami OA, Ahmed S, Karavitaki N. Epidemiology and mortality of Cushing's syndrome. Best Pract Res Clin Endocrinol Metab. 2021 Jan;35(1):101521. doi: 10.1016/j.beem.2021.101521. Epub 2021 Mar 15
Journal / Source Title
Best practice & research. Clinical endocrinology & metabolism
DOI
10.1016/j.beem.2021.101521
PMID
33766428
Publisher
Elsevier
Publisher’s URL
http://www.sciencedirect.com/science/journal/1521690X