Holter-ECG findings after acute ischemic stroke and TIA: a systematic analysis of the MonDAFIS randomized trial
Thießen, Niklas Olma, Manuel C Tütüncü, Serdar Jawad-Ul-Qamar, Muhammad Kunze, Claudia Thomalla, Götz Nabavi, Darius G Röther, Joachim Laufs, Ulrich Veltkamp, Roland
Thießen, Niklas
Olma, Manuel C
Tütüncü, Serdar
Jawad-Ul-Qamar, Muhammad
Kunze, Claudia
Thomalla, Götz
Nabavi, Darius G
Röther, Joachim
Laufs, Ulrich
Veltkamp, Roland
Abstract
Holter-ECG monitoring is a critical component of post-stroke diagnostics, guiding cardiac work-up and secondary stroke prevention. Abnormal ECG findings beyond atrial fibrillation (AF) in stroke patients remain understudied. The prospective multicenter MonDAFIS trial randomized patients with acute ischemic stroke or transient ischemic attack (TIA) without known AF to Holter-ECG recording up to 7 days or usual care. Holter-ECG findings from the first 72 h of the intervention arm were analyzed to provide a reference guide in clinical practice. Furthermore, 24-hour and 72-hour Holter-ECG monitoring were compared to analyze the value of prolonged monitoring. 24-hour Holter-ECGs from 1,665 patients (median age 67; 40.4% women) identified supraventricular tachycardia (SVT) in 4.1% and newly-diagnosed AF in 2.2% of patients. Premature ventricular complexes were common (85.8%), ventricular couplets (28.0%) or bigeminy (14.0%) less common. Non-sustained ventricular tachycardia (nsVT) was detected in 1.7% of patients. Extended 72-hour-monitoring in 1,283 patients led to higher detection rates across all abnormalities, doubling nsVT (4.4%) and SVT (8.8%) detection rates. Generally, we observed higher detection rates with older age. Detection rates of supraventricular arrhythmias were higher in women, whereas men exhibited higher rates of ventricular abnormalities. Post-stroke ECG monitoring detects various arrhythmias beyond AF in a substantial proportion of individuals. Longer monitoring and older age are associated with increased detection rates, with notable sex-specific differences.
MIDER Authors
Affiliations
University Medical Center Hamburg- Eppendorf (UKE); Charité - Universitätsmedizin Berlin; Alexianer St. Josefs-Krankenhaus Potsdam; Sandwell and West Birmingham NHS Trust; et al.
Date
2026-06-01
Type
Article
Collections
Citation
Thießen N, Olma MC, Tütüncü S, Jawad-Ul-Qamar M, Kunze C, Thomalla G, Nabavi DG, Röther J, Laufs U, Veltkamp R, Heuschmann PU, Kirchhof P, Endres M, Haeusler KG, Schnabel RB. Holter-ECG findings after acute ischemic stroke and TIA: A systematic analysis of the MonDAFIS randomized trial. Sci Rep. 2026 Jun 1;16(1):16812. doi: 10.1038/s41598-026-54603-z.