The clinical profile and associated mortality in people with and without diabetes with Coronavirus disease 2019 on admission to acute hospital services
Gokhale, Krishna Mostafa, Samiul A Wang, Jingya Tahrani, Abd A Sainsbury, Christopher Andrew Toulis, Konstantinos A Thomas, G Neil Hassan-Smith, Zaki Sapey, Elizabeth Gallier, Suzy
Gokhale, Krishna
Mostafa, Samiul A
Wang, Jingya
Tahrani, Abd A
Sainsbury, Christopher Andrew
Toulis, Konstantinos A
Thomas, G Neil
Hassan-Smith, Zaki
Sapey, Elizabeth
Gallier, Suzy
Abstract
Introduction: To assess if in adults with COVID-19, whether those with diabetes and complications (DM+C) present with a more severe clinical profile and if that relates to increased mortality, compared to those with diabetes with no complications (DM-NC) and those without diabetes.
Methods: Service-level data was used from 996 adults with laboratory confirmed COVID-19 who presented to the Queen Elizabeth Hospital Birmingham, UK, from March to June 2020. All individuals were categorized into DM+C, DM-NC, and non-diabetes groups. Physiological and laboratory measurements in the first 5 days after admission were collated and compared among groups. Cox proportional hazards regression models were used to evaluate associations between diabetes status and the risk of mortality.
Results: Among the 996 individuals, 104 (10.4%) were DM+C, 295 (29.6%) DM-NC and 597 (59.9%) non-diabetes. There were 309 (31.0%) in-hospital deaths documented, 40 (4.0% of total cohort) were DM+C, 99 (9.9%) DM-NC and 170 (17.0%) non-diabetes. Individuals with DM+C were more likely to present with high anion gap/metabolic acidosis, features of renal impairment, and low albumin/lymphocyte count than those with DM-NC or those without diabetes. There was no significant difference in mortality rates among the groups: compared to individuals without diabetes, the adjusted HRs were 1.39 (95% CI 0.95-2.03, p = 0.093) and 1.18 (95% CI 0.90-1.54, p = 0.226) in DM+C and DM-C, respectively.
Conclusions: Those with COVID-19 and DM+C presented with a more severe clinical and biochemical profile, but this did not associate with increased mortality in this study.
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Date
2021-12-03
Type
Article
Other
Other
Subject
Oncology. Pathology., Genetics
Citation
Gokhale K, Mostafa SA, Wang J, Tahrani AA, Sainsbury CA, Toulis KA, Thomas GN, Hassan-Smith Z, Sapey E, Gallier S, Adderley NJ, Narendran P, Bellary S, Taverner T, Ghosh S, Nirantharakumar K, Hanif W. The clinical profile and associated mortality in people with and without diabetes with Coronavirus disease 2019 on admission to acute hospital services. Endocrinol Diabetes Metab. 2022 Jan;5(1):e00309. doi: 10.1002/edm2.309. Epub 2021 Dec 3
Journal / Source Title
Endocrinology, Diabetes & Metabolism
DOI
10.1002/edm2.309
PMID
34859617
Publisher
John Wiley & Sons
Publisher’s URL
https://onlinelibrary.wiley.com/journal/23989238