The impact of perioperative NSAID use on pleurodesis following thoracic surgery
Kutywayo, Kudzayi Habib, Akolade Caruana, Edward
Kutywayo, Kudzayi
Habib, Akolade
Caruana, Edward
Abstract
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was: in patients who have had {visceral and parietal pleural symphysis}, {do NSAIDs reduce} {the efficacy of pleurodesis}? 16 papers were discovered in the search. Of these, 3 human studies were included in the analysis. None showed a significantly higher rate of pleurodesis failure in patients given perioperative NSAIDs. The results from the largest study met criteria for non-inferiority. Within the constraints of the study the results suggest that systemic administration of non-steroidal anti-inflammatory medication in the peri-operative period does not necessarily attenuate effective pleurodesis. However further study is needed as there is a clear paucity of human based studies.
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Date
04/09/2023
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Kutywayo, K., Habib, A. A., & Caruana, E. (2023). The impact of perioperative NSAID use on pleurodesis following thoracic surgery. Interdisciplinary cardiovascular and thoracic surgery, ivad107. Advance online publication. https://doi.org/10.1093/icvts/ivad107