The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background
Abstract
The roles of DGAT1 and DGAT2 in lipid metabolism and insulin responsiveness of human skeletal muscle were studied using cryosections and myotubes prepared from muscle biopsies from control, athlete, and impaired glucose regulation (IGR) cohorts of men. The previously observed increases in intramuscular triacylglycerol (IMTG) in athletes and IGR were shown to be related to an increase in lipid droplet (LD) area in type I fibers in athletes but, conversely, in type II fibers in IGR subjects.
Author
Citations
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Date
2023-11
Type
Article
Subject
Gastroenterology, Diabetes, Biochemistry
Collections
Citation
Zehra Irshad 1, Jenny Lund 2, Anne Sillars 3, Nils Gunnar Løvsletten 2, Seley Gharanei 1 4, Ian P Salt 5, Dilys J Freeman 3, Jason M R Gill 3, G Hege Thoresen 2 6, Arild C Rustan 2, Victor A Zammit 1
Journal / Source Title
The FASEB Journal
DOI
PMID
Publisher
Wiley
Publisher’s URL
DOI: 10.1096/fj.202300960RR
DOI: 10.1096/fj.202300960RR
DOI: 10.1096/fj.202300960RR