Recommendations to promote equity, diversity and inclusion in decentralized clinical trials
Abstract
Decentralized clinical trials involving the use of digital tools to facilitate remote research are gaining momentum. Rapid advancements in digital technologies have supported the adoption of these trials. These innovations facilitate virtual interactions between clinical trial teams and participants by making it easier to collect, transfer and store electronic data. While some studies have demonstrated the potential for these approaches to reduce barriers to clinical trial participation, they are associated with several challenges that may create or worsen existing health inequalities and limit the generalizability of trial results. Here we review the potential for digitally enabled and decentralized clinical trials to enhance clinical trial participation in an equitable manner. We describe the key barriers individuals from underserved groups may face, and provide recommendations to promote equity, diversity and inclusion.
Author
Aiyegbusi, Olalekan Lee
Cruz Rivera, Samantha
Kamudoni, Paul
Anderson, Nicola
Collis, Philip
Denniston, Alastair K
Harding, Rosie
Hughes, Sarah E
Khunti, Kamlesh
Kotecha, Dipak
Krumholz, Harlan
Liu, Xiaoxuan
McMullan, Christel
Molony-Oates, Barbara
Monteiro, Joao
Myles, Puja
Rantell, Khadija Rerhou
Soltys, Katherine
Verdi, Ravinder
Wilson, Roger
Calvert, Melanie J
Cruz Rivera, Samantha
Kamudoni, Paul
Anderson, Nicola
Collis, Philip
Denniston, Alastair K
Harding, Rosie
Hughes, Sarah E
Khunti, Kamlesh
Kotecha, Dipak
Krumholz, Harlan
Liu, Xiaoxuan
McMullan, Christel
Molony-Oates, Barbara
Monteiro, Joao
Myles, Puja
Rantell, Khadija Rerhou
Soltys, Katherine
Verdi, Ravinder
Wilson, Roger
Calvert, Melanie J
Citations
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Date
2024-10-29
Type
Article
Subject
Public health. Health statistics. Occupational health. Health education, Patients. Primary care. Medical profession. Forensic medicine, Sociology, Health services. Management
Collections
Citation
Aiyegbusi OL, Cruz Rivera S, Kamudoni P, Anderson N, Collis P, Denniston AK, Harding R, Hughes SE, Khunti K, Kotecha D, Krumholz H, Liu X, McMullan C, Molony-Oates B, Monteiro J, Myles P, Rantell KR, Soltys K, Verdi R, Wilson R, Calvert MJ. Recommendations to promote equity, diversity and inclusion in decentralized clinical trials. Nat Med. 2024 Nov;30(11):3075-3084. doi: 10.1038/s41591-024-03323-w. Epub 2024 Oct 29.
Journal / Source Title
Nature Medicine
DOI
10.1038/s41591-024-03323-w
PMID
39472759
Publisher
Nature Publishing Company
Publisher’s URL
https://libkey.io/libraries/2791/pmid/39472759