Predictors of the efficacy of his bundle pacing in patients with a prolonged PR interval: A stratified analysis of the HOPE-HF randomized controlled trial.
Abstract
The randomized, double-blind, placebo-controlled HOPE-HF trial assessed the benefit of atrio-ventricular (AV) delay optimization delivered using His bundle pacing. It recruited patients with left ventricular ejection fraction ≤40%, PR interval ≥200 ms, and baseline QRS ≤140 ms or right bundle branch block. Overall, there was no significant increase in peak oxygen uptake (VO2max) but there was significant improvement in heart failure specific quality of life. In this pre-specified secondary analysis, we evaluated the impact of baseline PR interval, echocardiographic E-A fusion, and the magnitude of acute high-precision haemodynamic response to pacing, on outcomes.
Author
Keene, Daniel
Kaza, Nandita
Srinivasan, Divya
Ali, Nadine
Tanner, Mark
Foley, Paul
Chandrasekaran, Badri
Moore, Philip
Adhya, Shaumik
Qureshi, Norman
Muthumala, Amal
Lane, Rebecca
Rinaldi, Aldo
Agarwal, Sharad
Leyva, Francisco
Behar, Jonathan
Bassi, Sukh
Ng, Andre
Scott, Paul
Prasad, Rachana
Swinburn, Jon
Tomson, Joseph
Sethi, Amarjit
Shah, Jaymin
Lim, Phang Boon
Kyriacou, Andreas
Thomas, Dewi
Chuen, Jenny
Kamdar, Ravi
Kanagaratnam, Prapa
Mariveles, Myril
Johnson, Nicholas
Falaschetti, Emanuela
Howard, James P
Arnold, Ahran
Cleland, John G F
Francis, Darrel P
Whinnett, Zachary
Shun-Shin, Matthew
Kaza, Nandita
Srinivasan, Divya
Ali, Nadine
Tanner, Mark
Foley, Paul
Chandrasekaran, Badri
Moore, Philip
Adhya, Shaumik
Qureshi, Norman
Muthumala, Amal
Lane, Rebecca
Rinaldi, Aldo
Agarwal, Sharad
Leyva, Francisco
Behar, Jonathan
Bassi, Sukh
Ng, Andre
Scott, Paul
Prasad, Rachana
Swinburn, Jon
Tomson, Joseph
Sethi, Amarjit
Shah, Jaymin
Lim, Phang Boon
Kyriacou, Andreas
Thomas, Dewi
Chuen, Jenny
Kamdar, Ravi
Kanagaratnam, Prapa
Mariveles, Myril
Johnson, Nicholas
Falaschetti, Emanuela
Howard, James P
Arnold, Ahran
Cleland, John G F
Francis, Darrel P
Whinnett, Zachary
Shun-Shin, Matthew
Citations
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Date
2024-07-18
Type
Article
Subject
Cardiology
Collections
Citation
Keene D, Kaza N, Srinivasan D, Ali N, Tanner M, Foley P, Chandrasekaran B, Moore P, Adhya S, Qureshi N, Muthumala A, Lane R, Rinaldi A, Agarwal S, Leyva F, Behar J, Bassi S, Ng A, Scott P, Prasad R, Swinburn J, Tomson J, Sethi A, Shah J, Lim PB, Kyriacou A, Thomas D, Chuen J, Kamdar R, Kanagaratnam P, Mariveles M, Johnson N, Falaschetti E, Howard JP, Arnold A, Cleland JGF, Francis DP, Whinnett Z, Shun-Shin M. Predictors of the efficacy of His bundle pacing in patients with a prolonged PR interval: A stratified analysis of the HOPE-HF randomized controlled trial. Eur J Heart Fail. 2024 Jul 18. doi: 10.1002/ejhf.3367. Epub ahead of print.
Journal / Source Title
European Journal of Heart Failure
DOI
10.1002/ejhf.3367
PMID
39023285
Publisher
Wiley
Publisher’s URL
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1879-0844