Historical outcomes for patients with stage IA NLPHL: Global NLPHL One Working Group retrospective analyses
Flerlage, Jamie E Eichenauer, Dennis A Fuchs, Michael Hartmann, Sylvia Eich, Hans Theodor Savage, Kerry J Lo, Andrea C Skinnider, Brian Akhtar, Saad Rauf, M Shahzad
Flerlage, Jamie E
Eichenauer, Dennis A
Fuchs, Michael
Hartmann, Sylvia
Eich, Hans Theodor
Savage, Kerry J
Lo, Andrea C
Skinnider, Brian
Akhtar, Saad
Rauf, M Shahzad
Abstract
We evaluated outcomes by management type for patients with stage IA nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) in the Global NLPHL One Working Group (GLOW) retrospective database of 2243 patients with stage I-IV disease diagnosed from 1992-2021 at 38 international institutions. 779 patients were stage IA with median age of 35 years (range=3-89) and median follow-up of 6.1 years. The 6-year PFS and OS were 86.3% and 97.7%, respectively. Outcomes were analyzed for two groups: complete resection and unresected disease. Patients with a complete resection and observation alone (n=99) had a 6-year PFS of 65.5% versus 90.5% for those who received RT (n=53). Patients with unresected disease (n=627; 80.5%) had a 6-year PFS of 62.0% for rituximab alone (n=31), 89.6% for RT alone (n=325), 76.8% for ABVD alone (n=40), and 94.3% for ABVD+RT (n=130). 127 patients relapsed (16.3%), of which 25 (19.7%) had transformation. Our analysis suggests 1) RT improves the PFS in patients with completely resected disease; 2) Rituximab or ABVD alone do not appear to achieve a durable response; 3) Chemotherapy was not observed to add additional PFS benefit when used in combination with RT. Thus, for stage IA NLPHL, RT alone is likely sufficient for definitive treatment.
MIDER Authors
Affiliations
Date
2026-04-14
Type
Article
Subject
Collections
Citation
Flerlage JE, Eichenauer DA, Fuchs M, Hartmann S, Eich HT, Savage KJ, Lo AC, Skinnider B, Akhtar S, Rauf MS, Maghfoor I, Pinnix CC, Steiner R, Milgrom SA, Vega F, Alomari M, Zhang XY, Collins GP, Advani RH, Kumar P, Dickinson M, Wirth A, Tsang R, Prica A, Major A, Smith S, Hendrickson PG, Kelsey CR, Hopkins D, McKay P, Ng A, Koenig J, Constine LS, Casulo C, Sakthivel G, Baron J, Plastaras JP, Roberts KB, Gao S, Al Kendi J, Al Rahbi N, Balogh A, Levis M, Ricardi U, Sridhar A, Torka P, Specht L, De Silva R, Shah N, Pickard K, Osborne W, Blazin LJ, Henry M, Chang I, Smith CM, Halperin D, Miall F, Brady JL, Mikhaeel G, Brennan B, Penn A, Senchenko MA, Volchkov EV, Reeves M, Hoppe B, Terezakis S, Talaulikar D, Della Pepa R, Picardi M, Kirova Y, Fergusson P, Northend M, Hawkes E, Lee D, Doo NW, Barraclough A, Opat S, Cheah CY, Salvaris R, Ku M, Hamad N, Mutsando H, Tedjaseputra A, Gilbertson M, Marconi T, Viiala N, Palese M, Shankar A, Maurer MJ, Natkunam Y, Kelly KM, Borchmann P, Hoppe RT, Binkley MS. Historical outcomes for patients with stage IA NLPHL: Global NLPHL One Working Group retrospective analyses. Blood Adv. 2026 Aug 11;10(15):5338-5347. doi: 10.1182/bloodadvances.2026020012.