Less social deprivation Is associated with better health-related quality of life in asthma and is mediated by less anxiety and better sleep quality.
Abstract
Background: Previous studies on health-related quality of life (HRQoL) in asthma have mainly focused on clinical and environmental determinants. Little is known about the role of social determinants on HRQoL in asthma.
Objectives: We aimed to investigate the association between social deprivation and HRQoL in asthma.
Methods: A total of 691 adult asthmatics from Canada, India, New Zealand, and the United Kingdom were administered a digital questionnaire containing demographic information and questions about social and psychological attributes, sleep disturbances, and alcohol abuse. HRQoL was measured using the Short Form of the Chronic Respiratory Questionnaire (SF-CRQ). We analyzed the direct and indirect relationships between social deprivation and HRQoL using structural equation models with social deprivation as a latent variable. We tested for mediation via anxiety, depression, sleep disturbances, and alcohol abuse.
Results: We found that less social deprivation (latent variable) was directly associated with better SF-CRQ domain scores such as dyspnea (regression coefficient β: 0.33; 95% confidence interval [CI]: 0.07 to 0.58), fatigue (β: 0.39; 95% CI: 0.14 to 0.64), and emotional function (β: 0.37; 95% CI: 0.11 to 0.62), but with the worse mastery score (β: -0.29; 95% CI: -0.55 to -0.03); however, those associations varied across participating countries. We also observed that among all individual social deprivation indicators, education, companionship, emotional support, instrumental support, and social isolation were directly associated with HRQoL, and the relationship between social deprivation and HRQoL was mediated through anxiety and sleep disturbances.
Author
Moitra, Subhabrata
Adan, Ana
Akgün, Metin
Anderson, Augustus
Brickstock, Amanda
Eathorne, Allie
Farshchi Tabrizi, Ali
Haldar, Prasun
Henderson, Linda
Jindal, Aditya
Jindal, Surinder Kumar
Kerget, Bugra
Khadour, Fadi
Melenka, Lyle
Moitra, Saibal
Moitra, Tanusree
Mukherjee, Rahul
Semprini, Alex
Turner, Alice M
Murgia, Nicola
Ferrara, Giovanni
Lacy, Paige
Adan, Ana
Akgün, Metin
Anderson, Augustus
Brickstock, Amanda
Eathorne, Allie
Farshchi Tabrizi, Ali
Haldar, Prasun
Henderson, Linda
Jindal, Aditya
Jindal, Surinder Kumar
Kerget, Bugra
Khadour, Fadi
Melenka, Lyle
Moitra, Saibal
Moitra, Tanusree
Mukherjee, Rahul
Semprini, Alex
Turner, Alice M
Murgia, Nicola
Ferrara, Giovanni
Lacy, Paige
Citations
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Date
2023-04-20
Type
Article
Subject
Respiratory medicine, Psychology, Diseases & disorders of systemic, metabolic or environmental origin
Citation
Moitra S, Adan A, Akgün M, Anderson A, Brickstock A, Eathorne A, Farshchi Tabrizi A, Haldar P, Henderson L, Jindal A, Jindal SK, Kerget B, Khadour F, Melenka L, Moitra S, Moitra T, Mukherjee R, Semprini A, Turner AM, Murgia N, Ferrara G, Lacy P. Less Social Deprivation Is Associated With Better Health-Related Quality of Life in Asthma and Is Mediated by Less Anxiety and Better Sleep Quality. J Allergy Clin Immunol Pract. 2023 Apr 20:S2213-2198(23)00407-5. doi: 10.1016/j.jaip.2023.03.052. Epub ahead of print.
Journal / Source Title
Journal of Allergy and Clinical Immunology: In Practice
DOI
10.1016/j.jaip.2023.03.052
PMID
37087095
Publisher
Elsevier
Publisher’s URL
http://www.sciencedirect.com/science/journal/22132198