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Case report on cycloserine serum levels after treatment with oral terizidone and oral cycloserine

Rose, Lauren
; 
Thompson, Jonathan
; 
Berry, Louise
; 
Venkatesan, Pradhib
Abstract
A 24 year old man with multi-drug resistant pulmonary tuberculosis was treated with a regime that included terizidone and then cycloserine. Serum drug levels of cycloserine were higher on milligram equivalent doses of cycloserine. Guidance implies that terizidone should be considered bioequivalent to cycloserine, but this case illustrates that this cannot be presumed. Any reduction in neuropsychiatric side-effects with terizidone may be due to lower cycloserine exposure and thereby reduced anti-mycobacterial efficacy. Copyright © 2023 The Authors
MIDER Authors
Rose, Lauren
Thompson, Jonathan
Berry, Louise
Venkatesan, Pradhib
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Date
2024-1
Type
Article
Subject
Tuberculosis
 Drug Monitoring
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NUH Infectious Diseases
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Citation
Rose, L., Thompson, J., Berry, L., Venkatesan, P. Case report on cycloserine serum levels after treatment with oral terizidone and oral cycloserine. Clin. Infect. Pract. 2024;21:no pagination. doi:10.1016/j.clinpr.2023.100335
Journal / Source Title
Clinical Infection in Practice
DOI
10.1016/j.clinpr.2023.100335
URI
https://hdl.handle.net/20.500.14200/11054
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Publisher
Elsevier
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