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Attainment of low disease activity and remission targets reduces the risk of severe flare and new damage in childhood lupus
Rangaraj, Satyapal
Rangaraj, Satyapal
Abstract
Objectives: To assess the achievability and effect of attaining low disease activity (LDA) or remission in childhood-onset SLE (cSLE). Method(s): Attainment of three adult-SLE derived definitions of LDA (LLDAS, LA, Toronto-LDA), and four definitions of remission (clinical-SLEDAI-defined remission on/off treatment, pBILAG-defined remission on/off treatment) was assessed in UK JSLE Cohort Study patients longitudinally. Prentice-Williams-Petersen gap recurrent event models assessed the impact of LDA/remission attainment on severe flare/new damage. Result(s): LLDAS, LA and Toronto-LDA targets were reached in 67%, 73% and 32% of patients, after a median of 18, 15 or 17 months, respectively. Cumulatively, LLDAS, LA and Toronto-LDA was attained for a median of 23%, 31% and 19% of total follow-up-Time, respectively. Remission on-Treatment was more common (61% cSLEDAI-defined, 42% pBILAG-defined) than remission off-Treatment (31% cSLEDAI-defined, 21% pBILAG-defined). Attainment of all target states, and disease duration (>1 year), significantly reduced the hazard of severe flare (P Result(s): LLDAS, LA and Toronto-LDA targets were reached in 67%, 73% and 32% of patients, after a median of 18, 15 or 17 months, respectively. Cumulatively, LLDAS, LA and Toronto-LDA was attained for a median of 23%, 31% and 19% of total follow-up-Time, respectively. Remission on-Treatment was more common (61% cSLEDAI-defined, 42% pBILAG-defined) than remission off-Treatment (31% cSLEDAI-defined, 21% pBILAG-defined). Attainment of all target states, and disease duration (>1 year), significantly reduced the hazard of severe flare (P 0.05). Attainment of all targets reduced the hazards of new damage (P 0.05). Attainment of all targets reduced the hazards of new damage (P Conclusion(s): This is the first study demonstrating that adult-SLE-derived definitions of LDA/remission are achievable in cSLE, significantly reducing risk of severe flare/new damage. Of the LDA definitions, LLDAS performed best, leading to a statistically comparable reduction in the hazards of severe flare to attainment of clinical remission.Copyright © 2021 The Author(s). Published by Oxford University Press on behalf of the British Society for Rheumatology.
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Date
2022
Type
Article
Subject
Lupus erythematosus, Follow-up studies, Treatment outcome
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Citation
Smith, E.M.D., Tharmaratnam, K., AlAbadi, E., Armon, K., Bailey, K., Brennan, M., Ciurtin, C., GardnerMedwin, J., Haslam, K.E., Hawley, D., Leahy, A., Leone, V., Malik, G., McLaren, Z., Pilkington, C., Ramanan, A.V., Rangaraj, S., Ratcliffe, A., Riley, P., Sen, E., Sridhar, A., Wilkinson, N., Hedrich, C.M., Jorgensen, A. and Beresford, M.W. (2022) 'Attainment of low disease activity and remission targets reduces the risk of severe flare and new damage in childhood lupus', Rheumatology, 61(8), pp. 3378-3389. doi: 10.1093/rheumatology/keab915 https://doi.org/10.1093/rheumatology/keab915.