The Microbiota-Human Health Axis
John, Harrie Toms Thomas, Treesa Clare Chukwuebuka, Ezenwa Collins Ali, Ali Bacar Anass, Reggani Tefera, Yididiya Yilma Babu, Bency Negrut, Nicoleta Ferician, Anca Marian, Paula
John, Harrie Toms
Thomas, Treesa Clare
Chukwuebuka, Ezenwa Collins
Ali, Ali Bacar
Anass, Reggani
Tefera, Yididiya Yilma
Babu, Bency
Negrut, Nicoleta
Ferician, Anca
Marian, Paula
Abstract
Trillions of microorganisms play a pivotal role in maintaining health and preventing disease in humans. Their presence influences daily life, habits, energy levels, and pathologies. The present narrative review synthesized recent studies of microbial diversity across organ systems. The composition of the microbiota regulates the intestinal barrier, modulates the immune response, influences metabolism, and produces essential compounds such as short-chain fatty acids and neurotransmitters. Dysbiosis is associated with numerous pathologies, including metabolic, autoimmune, neurodegenerative, and cardiovascular diseases. The microbiota is key to maintaining physiological balance and reducing disease risk. Therapeutic interventions, such as probiotics, prebiotics, postbiotics, and microbiome transplantation, offer promising perspectives in restoring microbial homeostasis and preventing chronic diseases.
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Date
2025
Type
Article
Subject
Collections
Citation
John HT, Thomas TC, Chukwuebuka EC, Ali AB, Anass R, Tefera YY, Babu B, Negrut N, Ferician A, Marian P. The Microbiota-Human Health Axis. Microorganisms. 2025 Apr 20;13(4):948. doi: 10.3390/microorganisms13040948