Guillain-Barre syndrome with asymmetrical weakness in a patient with Charcot-Marie-Tooth disease type 1A
Ahmed, Kawser Elachola, Mohammed Alsararatee, Hasan Pugh, Nichola
Ahmed, Kawser
Elachola, Mohammed
Alsararatee, Hasan
Pugh, Nichola
Abstract
A man in his 60s presented with acute, progressive right lower limb weakness, low back pain, and paraesthesia. Neuroimaging ruled out spinal cord and central pathology. Cerebrospinal fluid analysis revealed albumin-cytological dissociation, and nerve conduction studies confirmed Guillain-Barré syndrome (GBS) superimposed on Charcot-Marie-Tooth disease type 1A (CMT1A). There was no preceding infection or ganglioside antibody positivity. His weakness progressed rapidly, resulting in flaccid paralysis of the right leg. He received intravenous immunoglobulin with marked clinical improvement and regained independent mobility by follow-up. This case is notable for its atypical, asymmetrical presentation of GBS in the context of pre-existing hereditary neuropathy, posing diagnostic challenges. It contributes to the limited literature on overlapping GBS and CMT1A and reinforces the importance of early investigation and immunotherapy in non-classical cases. The case highlights that reflex loss and chronic neuropathy should not preclude consideration of acute treatable causes.
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Date
2025
Type
Article
Subject
Guillian-Barre Syndrome, Charcot-Marie-Tooth Disease, Muscle Weakness, Case Reports [Publication Type]
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Citation
Ahmed K, Elachola M, Alsararatee H, Pugh N. Guillain-Barré Syndrome With Asymmetrical Weakness in a Patient With Charcot-Marie-Tooth Disease Type 1A. Cureus. 2025 Oct 14;17(10):e94525. doi: 10.7759/cureus.94525.