Febrile convulsion and cervical lymphadenopathy as initial presentation of incomplete node-first Kawasaki disease.
Anjum, Muhammad Rafiq, Anjum
Anjum, Muhammad
Rafiq, Anjum
Abstract
Node-first Kawasaki disease (NFKD) is an atypical variant of Kawasaki disease (KD), presenting with fever and cervical lymphadenopathy before other classical features appear. This presentation often mimics bacterial cervical lymphadenitis (BCL), leading to misdiagnosis and treatment delays. We report a toddler initially treated for presumed BCL after presenting with a febrile convulsion and isolated lymphadenopathy. Failure to respond to antibiotics and the later appearance of rash, conjunctivitis and a small coronary artery aneurysm on echocardiography led to the diagnosis of incomplete NFKD. This case underscores the importance of early consideration of incomplete or atypical KD criteria in children with persistent fever and lymphadenopathy unresponsive to antibiotics. Delaying diagnosis until full clinical criteria develop may increase the risk of coronary complications. Early use of cardiac biomarkers, echocardiography and awareness of incomplete KD criteria can help distinguish KD from BCL, enabling timely diagnosis and treatment to improve outcomes.
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Date
2025
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Anjum M, Rafiq A. Febrile convulsion and cervical lymphadenopathy as initial presentation of incomplete node-first Kawasaki disease. BMJ Case Rep. 2025 Dec 3;18(12):e269493. doi: 10.1136/bcr-2025-269493.