Loading...
Changes in multimodality functional imaging parameters early during chemoradiation predict treatment response in patients with locally advanced head and neck cancer
Abstract
OBJECTIVE: To assess the optimal timing and predictive value of early intra-treatment changes in multimodality functional and molecular imaging (FMI) parameters as biomarkers for clinical remission in patients receiving chemoradiation for head and neck squamous cell carcinoma (HNSCC)., METHODS: Thirty-five patients with stage III-IVb (AJCC 7th edition) HNSCC prospectively underwent 18F-FDG-PET/CT, and diffusion-weighted (DW), dynamic contrast-enhanced (DCE) and susceptibility-weighted MRI at baseline, week 1 and week 2 of chemoradiation. Patients with evidence of persistent or recurrent disease during follow-up were classed as non-responders. Changes in FMI parameters at week 1 and week 2 were compared between responders and non-responders with the Mann-Whitney U test. The significance threshold was set at a p value of 17%, AUC 0.937)., CONCLUSION: Early intra-treatment changes in FDG-PET, DW and DCE MRI-derived parameters are predictive of ultimate response to chemoradiation in HNSCC. However, the optimal timing for assessment with FDG-PET parameters (week 1) differed from MRI parameters (week 2). This highlighted the importance of scanning time points for the design of FMI risk-stratified interventional studies.
Author
Citations
Altmetric:
Date
2018
Type
Article
Subject
Chemoradiotherapy, Diffusion magnetic resonance imaging, Head and neck neoplasms
Collections
Citation
Wong, K.H., Panek, R., Dunlop, A., Mcquaid, D., Riddell, A., Welsh, L.C., Murray, I., Koh, D., Leach, M.O., Bhide, S.A., Nutting, C.M., Oyen, W.J., Harrington, K.J. and Newbold, K.L. (2018) 'Changes in multimodality functional imaging parameters early during chemoradiation predict treatment response in patients with locally advanced head and neck cancer', European journal of nuclear medicine and molecular imaging, 45(5), pp. 759-767. doi: https://dx.doi.org/10.1007/s00259-017-3890-2.
Journal / Source Title
DOI
PMID
Publisher
Springer