Narrow-band imaging for the diagnosis of nonerosive reflux disease: An international, multicenter, randomized controlled trial
Beg, Sabina Fateen, Waleed Sami, Sarmed S. Ragunath, Krish
Beg, Sabina
Fateen, Waleed
Sami, Sarmed S.
Ragunath, Krish
Abstract
BACKGROUND AND AIMS: We examined the accuracy of narrow-band imaging (NBI) findings in nonerosive reflux disease (NERD) patients compared with control subjects and the impact of proton pump inhibitor (PPI) therapy on these mucosal changes in a multicenter, double-blind, randomized controlled trial. METHODS: NERD patients (typical symptoms using a validated GERD questionnaire, absence of erosive esophagitis, and abnormal 48-hour pH study) and control subjects underwent high-definition white-light endoscopy followed by NBI and biopsy sampling of the distal esophagus. Then, NERD patients were randomized to esomeprazole 40 mg/day or placebo for 8 weeks, followed by repeat endoscopy. The presence of distal esophageal mucosal changes on NBI were recorded at baseline and after treatment: intrapapillary capillary loops (IPCLs; number, dilation, and tortuosity), microerosions, increased vascularity, columnar islands, and ridge/villous pattern (RVP) above the squamocolumnar junction. RESULTS: Of 122 screened, 21 NERD and 21 control subjects were identified (mean age, 49.5 +/- 14.6 years; 62% men; and 85% white). The combination of IPCL tortuosity, RVP, and microerosions (62% vs 19%, P Copyright © 2022 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.
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Desai, M., Srinivasan, S., Sundaram, S., Dasari, C., Andraws, N., Mathur, S., Higbee, A., Miller, J., Beg, S., Fateen, W., Sami, S.S., Repici, A., Ragunath, K. and Sharma, P. (2022) 'Narrow-band imaging for the diagnosis of nonerosive reflux disease: An international, multicenter, randomized controlled trial', Gastrointestinal Endoscopy, 96(3), pp. 457-466.e3. doi: 10.1016/j.gie.2022.04.020 https://doi.org/10.1016/j.gie.2022.04.020.
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Available to view at the publisher's website here: https://doi.org/10.1016/j.gie.2022.04.020.