Quantifying the core deficit in classical schizophrenia
Rathnaiah, Mohanbabu Liddle, Elizabeth B. Kumar, Jyothika Katshu, Mohammad Z. Faruqi, Catherine Kelly, Christina Gill, Malkeet Liddle, Peter F.
Rathnaiah, Mohanbabu
Liddle, Elizabeth B.
Kumar, Jyothika
Katshu, Mohammad Z.
Faruqi, Catherine
Kelly, Christina
Gill, Malkeet
Liddle, Peter F.
Abstract
Background: For more than 100 years, disorganization and impoverishment of mental activity have been recognised as fundamental symptoms of schizophrenia. These symptoms may reflect a core brain process underlying persisting disability. Predisposition to persisting disability is a clinically important aspect of schizophrenia, yet the psychopathological processes predisposing to persisting disability are poorly understood. The delineation of a putative core deficit associated with persisting disability would be of potentially great value in delineating the underlying pathological processes and eventually in enhancing treatment. Aims: To derive scores for mental disorganization and impoverishment from commonly used rating scales, and test the hypothesis that disorganization and impoverishment, along with impaired cognition and role-function reflect a latent variable that is a plausible candidate for the putative core deficit.
MIDER Authors
Citations
Altmetric:
Date
2020
Type
Conference Proceeding
Subject
Collections
Citation
Rathnaiah, M., Liddle, E. B., Gascoyne, L., Kumar, J., Katshu, M. Z., Faruqi, C., Kelly, C., Gill, M., Robson, S., Brookes, M., et al. (2020). Quantifying the core deficit in classical schizophrenia. 2020 Schizophrenia International Research Society, 4-8 April 2020 Florence, Italy. Oxford: Schizophrenia Bulletin, p.S265-S266.