Novel treatment paradigms: primary IgA nephropathy
Barratt, Jonathan Cheung, Chee Kay Selvaskandan, Haresh
Barratt, Jonathan
Cheung, Chee Kay
Selvaskandan, Haresh
Abstract
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Approximately 30% to 45% of patients progress to kidney failure (KF) within 20 to 25 years of diagnosis, and there has long been a lack of effective treatments. The therapeutic landscape in IgAN is rapidly evolving, driven in large part by the acceptance of the surrogate clinical trial end point of proteinuria reduction by regulatory authorities for the accelerated approval of new therapies. Two drugs, targeted release formulation (TRF)-budesonide (nefecon) and sparsentan, have recently been approved under this scheme. Advancing insights into the pathophysiology of IgAN, including the roles of the mucosal immune system, B-cells, the complement system, and the endothelin system have driven development of therapies that target these factors. This review outlines current, recently approved, and emerging therapies for IgAN.
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Date
2023-12-01
Type
Article
Subject
APRIL, BAFF, IgA nephropathy, clinical trials, complement, endothelin
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Citation
Selvaskandan, H., Barratt, J., & Cheung, C. K. (2023). Novel Treatment Paradigms: Primary IgA Nephropathy. Kidney international reports, 9(2), 203–213. https://doi.org/10.1016/j.ekir.2023.11.026