Endovascular thrombectomy beyond 24 hours from ischemic stroke onset: a propensity score matched cohort study
Dhillon, Permesh Singh Podlasek, Anna McConachie, Norman Lenthall, Robert Nair, Sujit Malik, Luqman Dineen, Robert A.
Dhillon, Permesh Singh
Podlasek, Anna
McConachie, Norman
Lenthall, Robert
Nair, Sujit
Malik, Luqman
Dineen, Robert A.
Abstract
BACKGROUND: The safety and functional outcome of endovascular thrombectomy (EVT) in the very late (VL; >24 hours) time window from ischemic stroke onset remains undetermined. METHODS: Using data from a national stroke registry, we used propensity score matched (PSM) individual level data of patients who underwent EVT, selected with CT perfusion or non-contrast CT/CT angiography, between October 2015 and March 2020. Functional and safety outcomes were assessed in both late (6-24 hours) and VL time windows. Subgroup analysis was performed of imaging selection modality in the VL time window. RESULTS: We included 1150 patients (late window: 1046 (208 after PSM); VL window: 104 (104 after PSM)). Compared with EVT treatment initiation between 6 and 24 hours, patients treated in the VL window had similar modified Rankin Scale (mRS) scores at discharge (ordinal shift; common OR=1.08, 95% CI 0.69 to 1.47, p=0.70). No significant differences in achieving good functional outcome (mRS Copyright © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.
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Date
2023
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Dhillon, P.S., Butt, W., Podlasek, A., Barrett, E., McConachie, N., Lenthall, R., Nair, S., Malik, L., James, M.A., Dineen, R.A. and England, T.J. (2023) 'Endovascular thrombectomy beyond 24 hours from ischemic stroke onset: a propensity score matched cohort study', Journal of Neurointerventional Surgery, 15(3), pp. 233-237. doi: 10.1136/neurintsurg-2021-018591.