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The association between the multiple sclerosis screening questionnaire and objective measures of cognition: a systematic literature review and meta-analysis
Kontou, Eirini
Kontou, Eirini
Abstract
Introduction: The Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) is a self-report measure used to assess cognitive difficulties in people with Multiple Sclerosis (PwMS). The aim of this systematic review was to determine the associations between the MSNQ and: objective measures of cognition, measures of mood, and quality of life measures. Method: A comprehensive search was done across three databases (PsycINFO, MEDLINE, and CINAHL). A total of 15 studies, including 1992 participants, were selected for final inclusion. Meta-analyses were conducted to determine the pooled effect size of associations. Where data were not available for meta-analyses, a narrative synthesis approach was taken. Results: Significant, but small (r = −0.17), associations were found between the MSNQ and objective measures of cognition. Significant, moderate associations (r = 0.47) were found between the MSNQ and measures of mood. Conclusions: The small association between the MSNQ and objective measures of cognition shows that the measures do not converge well. However, their divergence may be important to map the broad construct of “cognitive ability” more fully. Limitations include a lack of reporting of non-significant effect sizes in individual studies. Clinical implications include the potential for the MSNQ to be used beyond being solely a proxy measure for objective cognition. Future research should investigate the associations between the informant version of the MSNQ and objective measures.
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Date
2023
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Article
Subject
Multiple sclerosis, Neuropsychology, Cognition
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Tunmore, J., Kontou, E., Moghaddam, N., Hufton, L. & Das Nair, R. (2023). The association between the multiple sclerosis screening questionnaire and objective measures of cognition: a systematic literature review and meta-analysis. Journal of Clinical and Experimental Neuropsychology, 45 (2), pp.197-217.
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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted
Manuscript in a repository by the author(s) or with their consent.
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