COVID-19 infection, admission and death among people with rare autoimmune rheumatic disease in England: Results from the RECORDER project
Rutter, Megan Lanyon, Peter C. Pearce, Fiona A.
Rutter, Megan
Lanyon, Peter C.
Pearce, Fiona A.
Abstract
Objectives: To calculate the rates of COVID-19 infection and COVID-19-related death among people with rare autoimmune rheumatic diseases (RAIRD) during the first wave of the COVID-19 pandemic in England compared with the general population. Method(s): We used Hospital Episode Statistics to identify all people alive on 1 March 2020 with ICD-10 codes for RAIRD from the whole population of England. We used linked national health records (demographic, death certificate, admissions and PCR testing data) to calculate rates of COVID-19 infection and death up to 31 July 2020. Our primary definition of COVID-19-related death was mention of COVID-19 on the death certificate. General population data from Public Health England and the Office for National Statistics were used for comparison. We also describe COVID-19-related hospital admissions and all-cause deaths. Result(s): We identified a cohort of 168 680 people with RAIRD, of whom 1874 (1.11%) had a positive COVID-19 PCR test. The age-standardized infection rate was 1.54 (95% CI: 1.50, 1.59) times higher than in the general population. A total of 713 (0.42%) people with RAIRD died with COVID-19 on their death certificate and the age-sex-standardized mortality rate for COVID-19-related death was 2.41 (2.30-2.53) times higher than in the general population. There was no evidence of an increase in deaths from other causes in the RAIRD population. Conclusion(s): During the first wave of COVID-19 in England, people with RAIRD had a 54% increased risk of COVID-19 infection and more than twice the risk of COVID-19-related death compared with the general population. These increases were seen despite shielding policies.Copyright © 2021 The Author(s). Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
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Date
2022
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Article
Subject
COVID-19, Rheumatic diseases, COVID-19 pandemic
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Rutter, M., Lanyon, P.C., Grainge, M.J., Hubbard, R., Peach, E., Bythell, M., Stilwell, P., Aston, J., Stevens, S. and Pearce, F.A. (2022) 'COVID-19 infection, admission and death among people with rare autoimmune rheumatic disease in England: Results from the RECORDER project', Rheumatology, 61(8), pp. 3161-3171. doi: 10.1093/rheumatology/keab794 https://doi.org/10.1093/rheumatology/keab794.
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Available to view on the publisher's website here: https://doi.org/10.1093/rheumatology/keab794.