Primary Hypercortisolism
Abstract
Primary hypercortisolism, commonly known as Cushing's syndrome, is an endocrine disorder characterized by excessive cortisol production by the adrenal glands, independent of adrenocorticotropic hormone stimulation. This disorder presents with a wide range of clinical manifestations, including metabolic, cardiovascular, and psychological disturbances, making its diagnosis and management complex. This document aims to provide a detailed review of primary hypercortisolism, including its pathophysiology, clinical presentation, diagnostic approaches, and treatment modalities. Special attention is given to the molecular mechanisms underlying cortisol overproduction, differential diagnosis from other forms of Cushing's syndrome, and the challenges posed by this condition in clinical practice.
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Date
2025-05
Type
Article
Subject
Cushing Syndrome, Hydrocortisone, Diagnosis, Differential
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Citation
Bravi CA. Primary Hypercortisolism. Urol Clin North Am. 2025 May;52(2):193-204. doi: 10.1016/j.ucl.2025.01.002. Epub 2025 Feb 26