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Incidence, prevalence and survival in patients with Langerhans cell histiocytosis: A national registry study from England, 2013-2019
Abstract
This analysis is the largest population-based study to date to provide contemporary and comprehensive epidemiological estimates of all third edition of the International Classification of Diseases for Oncology (ICD-O-3) coded Langerhans cell histiocytosis (LCH) from England. People of all ages were identified from the National Cancer Registration Dataset using ICD-O-3 morphologies 9751-9754 for neoplasms diagnosed in 2013-2019. A total of 658 patients were identified, of whom 324 (49%) were children aged =15 years. Prevalence of LCH was 9.95 (95% CI 9.14-10.81) per million persons at the end of 2019. The 1-year overall survival (OS) was 99% (95% CI 97%-100%) for children and 90% (95% CI 87%-93%) for adults. Those aged >=60 years had poorer OS than those aged =15 years. Prevalence of LCH was 9.95 (95% CI 9.14-10.81) per million persons at the end of 2019. The 1-year overall survival (OS) was 99% (95% CI 97%-100%) for children and 90% (95% CI 87%-93%) for adults. Those aged >=60 years had poorer OS than those aged =15 years. Prevalence of LCH was 9.95 (95% CI 9.14-10.81) per million persons at the end of 2019. The 1-year overall survival (OS) was 99% (95% CI 97%-100%) for children and 90% (95% CI 87%-93%) for adults. Those aged >=60 years had poorer OS than those aged Copyright © 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.
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Date
2022
Type
Article
Subject
International classification of diseases, Langerhans-cell hisiocytosis, Neoplasms
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Liu, H., Stiller, C.A., Crooks, C.J., Rous, B., Bythell, M., Broggio, J., Rankin, J., Nanduri, V., Lanyon, P., Card, T.R., Ban, L., Elliss-Brookes, L., Broughan, J.M., Paley, L., Wong, K., Bacon, A., Bishton, M. and West, J. (2022) 'Incidence, prevalence and survival in patients with Langerhans cell histiocytosis: A national registry study from England, 2013-2019', British Journal of Haematology, 199(5), pp. 728-738. doi: 10.1111/bjh.18459 https://doi.org/10.1111/bjh.18459.