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Dementia risk prediction modelling in low- and middle-income countries: Current state of evidence
Brain, Jacob Stephan, Blossom C. M.
Brain, Jacob
Stephan, Blossom C. M.
Abstract
Dementia is a leading cause of death and disability with over 60% of cases residing in low- and middle-income countries (LMICs). Therefore, new strategies to mitigate risk are urgently needed. However, despite the high burden of disease associated with dementia in LMICs, research into dementia risk profiling and risk prediction modelling is limited. Further, dementia risk prediction models developed in high income countries generally do not transport well to LMICs suggesting that context-specific models are instead needed. New prediction models have been developed, in China and Mexico only, with varying predictive accuracy. However, none has been externally validated or incorporated variables that may be important for predicting dementia risk in LMIC settings such as socio-economic status, literacy, healthcare access, nutrition, stress, pollutants, and occupational hazards. Since there is not yet any curative treatment for dementia, developing a context-specific dementia prediction model is urgently needed for planning early interventions for vulnerable groups, particularly for resource constrained LMIC settings.
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2024
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Alshahrani, M., Sabatini, S., Mohan, D., Brain, J., Pakpahan, E., Tang, E. Y. H., Robinson, L., Siervo, M., Naheed, A. & Stephan, B. C. M. (2024). Dementia risk prediction modelling in low- and middle-income countries: Current state of evidence. Frontiers in Epidemiology, 4, pp.1397754.
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© 2024 Alshahrani, Sabatini, Mohan, Brain,
Pakpahan, Tang, Robinson, Siervo, Naheed
and Stephan. This is an open-access article
distributed under the terms of the Creative
Commons Attribution License (CC BY). The
use, distribution or reproduction in other
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author(s) and the copyright owner(s) are
credited and that the original publication in
this journal is cited, in accordance with
accepted academic practice. No use,
distribution or reproduction is permitted
which does not comply with these terms.
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