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Pramipexole augmentation for the acute phase of treatment-resistant, unipolar depression : a placebo-controlled, double-blind, randomised trial in the UK
Abstract
BackgroundAbout 30% of patients with depression treated with antidepressant medication do not respond sufficiently to the first agents used. Pramipexole might usefully augment antidepressant medication in such cases of treatment-resistant depression, but data on its effects and tolerability are scarce. We aimed to assess the efficacy and tolerability of pramipexole augmentation of ongoing antidepressant treatment, over 48 weeks, in patients with treatment-resistant depression.
Author
Browning, Michael
Cowen, Philip J
Galal, Ushma
Baldwin, Ashley
Cleare, Anthony J
Evans, Jonathan
Huys, Quentin J M
Kessler, David
Kurkar, Micheal
Nixon, Neil
Rastogi, Abhinav
Watson, Stuart
Yu, Ly-Mee
Mort, Sam
Simon, Judit
Laszewska, Agata
Lewis, Alexander C
Roberts, Sophie M
Fiske, Victoria
Frending, Lisa M
Money, Catherine
Godlewska, Beata R
Ryland, Howard T
Halahakoon, Don Chamith
Wright, Laurence Astill
Salas, Barbara
Peddada, Apoorva
Wahba, Mourad
Taylor, Katharine S
Kerr-Gaffney, Jess
Swiffen, Duncan
Zangani, Caroline
Smith, Katharine A
Harmer, Catherine J
Geddes, John R
Cowen, Philip J
Galal, Ushma
Baldwin, Ashley
Cleare, Anthony J
Evans, Jonathan
Huys, Quentin J M
Kessler, David
Kurkar, Micheal
Nixon, Neil
Rastogi, Abhinav
Watson, Stuart
Yu, Ly-Mee
Mort, Sam
Simon, Judit
Laszewska, Agata
Lewis, Alexander C
Roberts, Sophie M
Fiske, Victoria
Frending, Lisa M
Money, Catherine
Godlewska, Beata R
Ryland, Howard T
Halahakoon, Don Chamith
Wright, Laurence Astill
Salas, Barbara
Peddada, Apoorva
Wahba, Mourad
Taylor, Katharine S
Kerr-Gaffney, Jess
Swiffen, Duncan
Zangani, Caroline
Smith, Katharine A
Harmer, Catherine J
Geddes, John R
Citations
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Date
2025
Type
Article
Subject
Major depressive disorder, Depression, Drug therapy
Collections
Citation
Browning, M., Cowen, P. J., Galal, U., Baldwin, A., Cleare, A. J., Evans, J., Huys, Q. J. M., Kessler, D., Kurkar, M., Nixon, N., et al. (2025). Pramipexole augmentation for the acute phase of treatment-resistant, unipolar depression : a placebo-controlled, double-blind, randomised trial in the UK. The Lancet Psychiatry, 12 (8), pp.579-589.
Journal / Source Title
DOI
PMID
Publisher
Elsevier
Publisher’s URL
Publisher’s statement
2025 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0
license.
Files
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