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Flowrna in the Diagnosis of EBV-Related Lymphoproliferative Disease
Jones, Steve
Jones, Steve
Abstract
Epstein-Barr (EBV) viraemia is frequently encountered in the context of haemophagocytic lymphohistiocytosis (HLH), systemic inflammation and lymphoproliferative disease (LPD). Although EBV typically infects B lymphocytes triggering both polyclonal proliferation and lymphoma, EBV can also infect T and NK cells. Understanding the phenotype of EBV-infected cells can help identify the underlying diagnosis and guide the use of appropriate targeted therapy. We have developed an EBV FlowRNA assay combining the detection of EBV-encoded small RNA (EBER) with multicolour flow cytometry (Collins, Blood, 2020). Here we present a larger case series illustrating how this assay can be used in diagnostic workup.
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Date
2023-11
Type
Article
Subject
Epstein-Barr viraemia, (EBV), Haemophagocytic lymphohistiocytosis, HLH
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Citation
Glover, A. et al. (2023) ‘Flowrna in the Diagnosis of EBV-Related Lymphoproliferative Disease’, Blood, 142(Supplement 1), p. 3660
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DOI
PMID
Publisher
Blood