Loading...
Impaired striatal glutamate/GABA regulation in violent offenders with antisocial personality disorder and psychopathy
Tully, John
Tully, John
Abstract
Men with antisocial personality disorder (ASPD) with or without psychopathy (+/−P) are responsible for most violent crime in society. Development of effective treatments is hindered by poor understanding of the neurochemical underpinnings of the condition. Men with ASPD with and without psychopathy demonstrate impulsive decision-making, associated with striatal abnormalities in functional neuroimaging studies. However, to date, no study has directly examined the potential neurochemical underpinnings of such abnormalities. We therefore investigated striatal glutamate: GABA ratio using Magnetic Resonance Spectroscopy in 30 violent offenders (16 ASPD-P, 14 ASPD + P) and 21 healthy non-offenders. Men with ASPD +/− P had a significant reduction in striatal glutamate : GABA ratio compared to non-offenders. We report, for the first time, striatal Glutamate/GABA dysregulation in ASPD +/− P, and discuss how this may be related to core behavioral abnormalities in the disorders.
MIDER Authors
Citations
Altmetric:
Date
2024
Type
Article
Subject
Personality disorders, Violence, Psychopathology
Collections
Citation
Tully, J., Pereira, A. C., Sethi, A., Griem, J., Cross, B., Williams, S. C. R., Blair, R. J., Murphy, D. & Blackwood, N. (2024). Impaired striatal glutamate/GABA regulation in violent offenders with antisocial personality disorder and psychopathy. Molecular Psychiatry, DOI: 10.1038/s41380-024-02437-4.
Journal / Source Title
DOI
PMID
Publisher
Publisher’s URL
Publisher’s statement
© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Files
Loading...
Tully 2024 1-9.pdf
Adobe PDF, 737.97 KB