Oral cavity cancers: ethnic differences in radiotherapy outcomes in a majority South Asian Leicester community
Patil, N Mair, M Nazareth, Joshua Sim, A Reynolds, C Freeman, N Chauhan, M Ahmad, S Sridhar, T Walter, H
Patil, N
Mair, M
Nazareth, Joshua
Sim, A
Reynolds, C
Freeman, N
Chauhan, M
Ahmad, S
Sridhar, T
Walter, H
Abstract
Aims: Squamous cell carcinoma oral cavity cancers (SCCOCCs) have a higher reported incidence in South Asian countries. We sought to compare presenting stage and outcome by ethnicity in patients with SCCOCC treated with radical radiotherapy in a single centre in the UK.
Materials and methods: All patients with SCCOCC treated with radical radiotherapy at an oncology department in Leicester (UK) between 2011 and 2017 were identified. Baseline demographic, clinical data and 2-year treatment outcomes were reported.
Results: Of the 109 patients included, 40 were South Asian and 59 were non-South Asian. South Asians had significantly poorer 2-year disease-free survival compared with non-South Asians (54.6% versus 73%, P = 0.01).
Conclusion: Our analysis suggests that South Asians with SCCOCC have poorer outcomes despite a younger age and similar disease characteristics. Environmental, social factors and differing biology of disease may be responsible and further research is required to inform targeted interventions.
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Date
2024-02-15
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Patil, N., Ma, N., Mair, M., Nazareth, J., Sim, A., Reynolds, C., Freeman, N., Chauhan, M., Howells, L., Peel, D., Ahmad, S., Sridhar, T., & Walter, H. S. (2024). Oral Cavity Cancers: Ethnic Differences in Radiotherapy Outcomes in a Majority South Asian Leicester Community. Clinical oncology (Royal College of Radiologists (Great Britain)), S0936-6555(24)00077-3. Advance online publication. https://doi.org/10.1016/j.clon.2024.02.010