Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction
Banerjee, Jaydip
Banerjee, Jaydip
Abstract
The objective of this study was to evaluate the association between frailty, evaluated by the Clinical Frailty Scale (CFS) and FRAIL scale, and C-terminal agrin fragment (CAF) levels with 3-month mortality following ST-segment elevation myocardial infarction (STEMI). This was a prospective observational study that included patients over the age of 18 years with STEMI admitted to the coronary intensive care unit. Within 48 h of admission, the CFS and FRAIL scale were applied and blood samples collected for serum CAF evaluation. Patients were followed for 3 months after hospital discharge, and mortality was recorded. One hundred and eleven patients were included; mean age was 62.3 ± 12.4 years, 61.3% were male and 11.7% died during the 3 months of follow-up. According to the CFS, 79.3% of the patients were classified as not frail, 12.6% as pre-frail and 8.1% as frail. According to the FRAIL scale, 31.5% of the patients were classified as not frail, 53.2% as pre-frail and 15.3% as frail. In univariate analysis, the CFS but not FRAIL scale was associated with mortality. In multiple logistic regression analysis, pre-frail/frail according to CFS (odds ratio [OR]: 6.118; CI 95%: 1.344-27.848; p = 0.019) and CAF levels (OR: 0.943; CI 95%: 0.896-0.992; p = 0.024) were associated with increased 3-month mortality. In a sub-analysis of 53 patients ≥65 years, CFS and CAF levels were associated with 3-month mortality. In conclusion, CAF levels and frailty determined by the CFS were associated with 3-month mortality after STEMI in the general and older population.
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Date
2022
Type
Article
Subject
acute myocardial infarction, C-terminal agrin fragment, clinical frailty scale, FRAIL scale, frailty
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Citation
de Souza Ramos, J., Ferrari, F. S., Andrade, M. F., de Melo, C. S., Boas, P., Costa, N. A., Pereira, A. G., Dorna, M. S., Azevedo, P. S., Banerjee, J., Phillips, B. E., Atherton, P. J., Polegato, B. F., Okoshi, K., Zanati, S. G., Paiva, S., Zornoff, L., & Minicucci, M. F. (2022). Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction. Experimental gerontology, 158, 111658. https://doi.org/10.1016/j.exger.2021.111658