Probing the biological underpinnings of advanced brain ageing in schizophrenia [in press]
Abstract
Background: Recent evidence suggests that patients with schizophrenia may show advanced brain ageing, particularly evident after the first year of onset. However, it is unclear if accelerated ageing relents, persists or continues to increase over time. The underlying causal factors are also poorly understood. Disruptions in glutamate function, oxidative stress, and inflammation may all contribute to progressive brain changes in people with schizophrenia. We examine whether brain ageing differs between early and established stages of schizophrenia, correlates with symptom severity and varies with markers of brain function, oxidative status and inflammatory burden.
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Date
2024
Type
Article
Subject
Schizophrenia, Brain, Aging, Article in press
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Citation
Murray, A. J., Ballester, P. L., Rogers, J. C., Williams, S., Wilson, M., Deakin, B., Katshu, M., Liddle, P., Palaniyappan, L. & Upthegrove, R. (2024). Probing the biological underpinnings of advanced brain ageing in schizophrenia [in press].