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Neutropenia Induced by Ceftriaxone and Meropenem
Abstract
Neutropenia by non-chemotherapy drugs is an extremely rare idiosyncratic life-threatening drug reaction. Ceftriaxone and meropenem are widely used broad-spectrum antibiotics and are generally safe and well tolerated. The authors present a case of neutropenia induced by ceftriaxone and meropenem in an adult patient. The resolution of neutropenia occurred within 48 hours of ceftriaxone and meropenem being discontinued. Although antibiotic-induced neutropenia is uncommon, clinicians should be mindful of this adverse drug effect because of its potential development of severe neutropenia, septicaemia, septic shock, deep-seated infections and even death. Therefore, neutropenic sepsis treatment should be initiated without delay, particularly if the patient becomes septic and febrile. Granulocyte-colony stimulation factor (G-CSF) may be administered to facilitate the recovery process with daily monitoring of neutrophil count. Mortalities from antibiotic-induced neutropenia remain rare, with a range of 2.5–5%.
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Date
2024
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Article
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Neutrophils, Anti-Bacterial Agents, Drug-Related Side Effects and Adverse Reactions, Case Reports
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Aung ZY, Elmagraby K, and Nicca, A (2024) Neutropenia Induced by Ceftriaxone and Meropenem. European Journal of Case Reports in Internal Medicine 11(7). Available from https://doi.org/10.12890/2024_004593
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